3-Carboxy-5-fluorophenylboronic acid is an important intermediate which is widely used in organic synthesis.We now introduce one method to produce it with total yield of 75.5%.This synthetic route is simple with low price of raw material and can be industrial production.
Step 1:
Use 3-Bromo-5-fluorotoluene as raw material.Organic lithium reagent is used to synthesize 3-Fluoro- 5-methylbenzeneboronic acid.The yield is 96.6%.Do 1H-NMR to confirm structure.
Step 2:
Oxidation reaction is usde to synthesize 3-Carboxy-5-fluorophenylboronic acid from
3-Fluoro-5-methylbenzeneboronic acid.Do 1H-NMR to confirm structure.
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